Explore Setmelanotide dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
Setmelanotide (Imcivree) is a melanocortin-4 receptor (MC4R) agonist approved for chronic weight management in rare genetic forms of obesity such as POMC, PCSK1, and LEPR deficiency, acting on the central pathway that regulates hunger and energy balance. It is dosed at the mg level once daily. This data shows the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when reconstituting Setmelanotide.
Setmelanotide is a cyclic peptide MC4R agonist approved as Imcivree for rare genetic obesity, sourced in research for appetite and weight studies. It ships as a lyophilized powder reconstituted before use.
Setmelanotide selectively activates MC4R, the central melanocortin receptor in the hypothalamic arcuate nucleus that mediates the leptin–POMC–MC4R appetite-regulation pathway. In patients with genetic disruptions upstream of MC4R (POMC, PCSK1, LEPR deficiency, BBS), MC4R signalling is impaired despite intact downstream receptor function — setmelanotide bypasses the upstream defect by directly activating the receptor, restoring satiety signalling.
, Lancet Diabetes Endocrinol 2020) reported clinically meaningful weight loss in 80% and 45% of treated patients respectively at 1 year, supporting the 2020 FDA approval. 9% mean BMI reduction at 52 weeks and was the basis for the 2022 BBS label extension. Setmelanotide is the first targeted pharmacotherapy for rare monogenic obesity, and active trials extend its use to additional rare genetic forms (hypothalamic obesity post-craniopharyngioma; SRC1, LEPR, PCSK1 heterozygous carriers).
Setmelanotide has a reported half-life of ~11 hours, and the dose intervals researchers model most often fall around once daily. An ~11-hour half-life with once-daily dosing gives modest buildup over the first day or two to a steady level, with some clearance overnight between doses. It is catalogued under Weight Loss on WPA.
The WPA community has not yet logged enough Setmelanotide calculator sessions to publish dose, vial size, or bacteriostatic water distributions for it. This page therefore covers what is known about the compound itself; the usage charts fill in as researchers run the calculator.
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.