Explore S-23 dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator data.
S-23 is a potent oral SARM — a small molecule, not a peptide — best known from a rat male-contraception study and sourced in research for muscle work. It is sold as a research chemical (capsules or an oral liquid).
S-23 binds the androgen receptor as a full agonist in skeletal muscle and prostate; the pre-clinical contraception rationale rested on its strong central-axis suppression of LH and FSH (and therefore endogenous testosterone and spermatogenesis) at doses that maintained sufficient peripheral AR signalling to preserve libido and secondary-sex-characteristic tissue.[1][3] Among consumer SARMs, S-23 is generally reported as one of the most-suppressive of endogenous testosterone, consistent with its full-agonist character at hypothalamic AR.
Jones et al. (Endocrinology 2009) characterised S-23 as a candidate for non-steroidal hormonal male contraception in rats; combined with estradiol, S-23 produced reversible azoospermia.[1] Beyond this and related Kaken/UTHSC pre-clinical work, the S-23 literature is sparse. There is no registered ClinicalTrials.gov trial of S-23 in any indication, no published human pharmacokinetic study, and no published controlled safety data in humans.[4] S-23 is therefore a research compound whose entire safety and efficacy footprint in consumer use is undocumented in the peer-reviewed literature.
Not FDA-approved. No registered clinical trial. Pre-clinical (rat) data only. WADA-prohibited at all times. Research-grade material only.
S-23 has a reported half-life of ~12 hours (pre-clinical estimate). The pharmacokinetic reference models an interval of once or twice daily; this is not a measured community cadence or a dosing recommendation. An estimated half-life of around half a day means twice-daily dosing keeps this oral SARM at a fairly steady level. Human PK data do not exist. Pharmacokinetic source: Pre-clinical (animal) data only; not characterised in humans. It is catalogued under Other Peptides on WPA.
The WPA community has not yet logged enough S-23 calculator sessions to publish dose, vial size, or bacteriostatic water distributions for it. This page therefore covers what is known about the compound itself; the usage charts fill in as researchers run the calculator.
These figures come from anonymized WPA peptide calculator sessions, not verified administrations or unique people. Separate modal inputs do not establish a joint protocol. They are community input statistics — not dosing recommendations, and not medical advice.
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.