Explore PNC-28 dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator data.
PNC-28 is a chimeric p53-derived peptide in the same research series as PNC-27, studied preclinically for selective cancer-cell membrane lysis. It is a research-only molecule that ships as a lyophilized powder, so the meaningful vendor difference is what the certificate of analysis (COA) shows.
PNC-28 uses the same mechanistic logic as PNC-27 — p53-fragment binding to anomalously surface-displayed HDM-2 on cancer cells, followed by membrane insertion and pore-forming necrosis. The companion paper specifically attributes the necrotic (rather than apoptotic) outcome to the penetratin-family membrane sequence rather than the p53 fragment.[1] Reported selectivity for transformed vs. non-transformed cells in vitro parallels the PNC-27 results.
Bowne, Sarafraz-Yazdi, and colleagues have published pre-clinical work on PNC-28 in pancreatic and other solid-tumour cell lines and mouse xenograft models from the same group that developed PNC-27.[1][2] No human clinical trial has been registered, and no major independent replication of the selectivity mechanism has been published.[3]
Not FDA-approved. No registered human clinical trial. Pre-clinical work limited largely to the originating group. Research-grade material for non-clinical use; selectivity claims are pre-clinical only.
PNC-28 has a reported half-life of ~30 min (pre-clinical estimate). The pharmacokinetic reference models an interval of once daily; this is not a measured community cadence or a dosing recommendation. Like PNC-27, this p53-derived membrane-disrupting peptide clears from plasma quickly with no systemic buildup; its action is driven by local exposure rather than a steady level. Pharmacokinetic source: Pre-clinical (cell/animal) studies only; not characterised in humans. It is catalogued under Other Peptides on WPA.
4 PNC-28 reconstitution calculations have been logged by the WPA community.
This is the lifetime header population. Each chart and its associated analysis below use their own selected period and denominator; frequency responses are a separate cohort.
These figures come from anonymized WPA peptide calculator sessions, not verified administrations or unique people. Separate modal inputs do not establish a joint protocol. They are community input statistics — not dosing recommendations, and not medical advice.
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.