Explore Phenibut dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator data.
Phenibut is a GABA-derived calming compound (a small molecule, not a peptide) developed in the Soviet Union and sourced for anxiety and sleep research. It ships as a powder or capsules.
Phenibut is a full agonist at GABA-B receptors (the same receptor targeted by baclofen) and a weak agonist at GABA-A receptors. It also acts as a calcium-channel blocker at α2δ subunits (the gabapentin/pregabalin target) at higher doses. The combination of GABA-B agonism and α2δ binding underlies its anxiolytic-with-sedation profile and its substantial dependence and withdrawal liability.[2]
Russian-language clinical literature reports use in generalized anxiety disorder, post-stroke asthenia, alcohol-withdrawal protocols, vestibular disorders, and pre-operative anxiety.[3] In the United States, the FDA issued warning letters in 2019 and 2021 against marketing phenibut-containing supplements as dietary ingredients, on the grounds that it does not meet the statutory definition of a dietary ingredient and that case reports of severe withdrawal and abuse make supplement marketing inappropriate.[4]
Registered as a prescription anxiolytic in Russia, Belarus, Latvia, and Ukraine. **Not FDA-approved in the United States** — FDA warning letters 2019 and 2021 against supplement marketing. **Schedule 9 in Australia (TGA, since 2018)** — possession is a criminal offence. Hospitalisations for phenibut withdrawal documented in US, UK, and Australian case literature.
Phenibut has a reported half-life of ~5 hours. The pharmacokinetic reference models an interval of once or twice daily; this is not a measured community cadence or a dosing recommendation. A roughly 5-hour half-life means phenibut clears largely between doses; spacing doses and avoiding daily use is important because tolerance and dependence build quickly. Pharmacokinetic source: Lapin, CNS Drug Rev 2001 (phenibut pharmacology). It is catalogued under Other Peptides on WPA.
The WPA community has not yet logged enough Phenibut calculator sessions to publish dose, vial size, or bacteriostatic water distributions for it. This page therefore covers what is known about the compound itself; the usage charts fill in as researchers run the calculator.
These figures come from anonymized WPA peptide calculator sessions, not verified administrations or unique people. Separate modal inputs do not establish a joint protocol. They are community input statistics — not dosing recommendations, and not medical advice.
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.