Explore NSI-189 dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator data.
NSI-189 is an experimental small molecule (not a peptide) studied for depression and to grow new hippocampal neurons, sourced in research for mood and neurogenesis work. It ships as capsules or a powder.
NSI-189 stimulates proliferation of hippocampal neural progenitor cells in vitro and expands the dentate gyrus in rodents after oral dosing, by a mechanism that has not been fully characterised at the receptor level. It does not engage the monoamine reuptake transporters or the serotonin/norepinephrine receptors targeted by classical antidepressants.[2]
A 24-patient Phase 1b in MDD reported numerical improvement on multiple depression scales with chronic oral dosing.[3] The Neuralstem-sponsored Phase 2 trial (NEWS) in 220 MDD patients did **not** meet its primary endpoint of MADRS reduction at 12 weeks at either dose tested (40 mg QD, 40 mg BID), and the depression program was effectively discontinued.[4]
Not FDA-approved. Phase 2 MDD program failed primary endpoint (NEWS trial, 2017). Sold by research-peptide vendors as a research-only material.
NSI-189 has a reported half-life of ~17–20 hours. The pharmacokinetic reference models an interval of once daily; this is not a measured community cadence or a dosing recommendation. A roughly 20-hour half-life supports once-daily dosing, with the compound accumulating over a few days to a steady level. Pharmacokinetic source: NSI-189 phase 1 human pharmacokinetic study. It is catalogued under Other Peptides on WPA.
The WPA community has not yet logged enough NSI-189 calculator sessions to publish dose, vial size, or bacteriostatic water distributions for it. This page therefore covers what is known about the compound itself; the usage charts fill in as researchers run the calculator.
These figures come from anonymized WPA peptide calculator sessions, not verified administrations or unique people. Separate modal inputs do not establish a joint protocol. They are community input statistics — not dosing recommendations, and not medical advice.
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.