Explore MOTS-c dosage trends, reconstitution data, and vial size patterns from anonymized WPA peptide calculator entries.
MOTS-c is a mitochondria-derived peptide encoded within the mitochondrial 12S rRNA region, with emerging research linking it to metabolic regulation and longevity. This data surfaces the dose amounts, vial sizes, and diluent volumes researchers most commonly select when setting up their MOTS-c reconstitution protocol.
MOTS-c is a 16-amino-acid peptide encoded by a small open reading frame within the 12S rRNA region of mitochondrial DNA — one of the founding members of the mitochondrial-derived peptide (MDP) family that the Pinchas Cohen group at USC characterized through the 2010s. Most DNA lives in the cell nucleus, but mitochondria — the energy factories inside every cell — carry their own small, separate strand of DNA, and MOTS-c is one of the peptides encoded there.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide most often sourced for metabolic, exercise, and aging research. It ships as a lyophilized powder reconstituted with bacteriostatic water, and all evidence to date is pre-clinical.
MOTS-c translocates to the nucleus under metabolic stress where it modulates expression of nuclear-encoded metabolic genes via AMPK activation, improves insulin sensitivity in skeletal muscle, and increases glucose uptake. It is one of a growing class of small mitochondrial-encoded peptides that signal between organelles.
Mouse studies have shown improvements in age-related insulin resistance, diet-induced obesity, and exercise capacity. No published Phase 2/3 human trials exist; MOTS-c remains a pre-clinical research peptide with active investigation into its role in metabolic aging and exercise mimetic activity.
MOTS-c has a reported half-life of ~4 hours, and the dose intervals researchers model most often fall around weekly. Short half-life relative to a weekly cadence means plasma MOTS-c clears almost entirely between doses. The downstream metabolic effects are thought to outlast the plasma half-life. It is catalogued under Weight Loss on WPA.
9,521 MOTS-c reconstitution calculations have been logged by the WPA community. The most common dose entered is 5mg (3,029 calculations). The median dose across all sessions is 2.5mg. The most common bacteriostatic water volume is 2mL. The most popular vial size is 40mg (4,745 sessions). The most common dosing frequency is once weekly (1,095 logged protocols), followed by 2x/week (992).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.