Explore MIF-1 dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
MIF-1 (melanocyte-stimulating-hormone release-inhibiting factor, Pro-Leu-Gly-NH2) is a short tripeptide derived from oxytocin, studied for its proposed neuromodulatory and antidepressant-like effects and its influence on dopaminergic signaling. It is dosed at the mcg-to-mg level depending on the research model. This data shows the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when reconstituting MIF-1.
MIF-1 is the Pro-Leu-Gly-NH₂ tripeptide (an oxytocin fragment) studied for opioid-system and mood-related research. It ships as a lyophilized powder you reconstitute before use, so the real vendor difference is what the certificate of analysis (COA) shows.
MIF-1 and its Tyr-MIF-1 family members act primarily as endogenous antagonists of opioid receptors — Tyr-MIF-1 binds the mu-opioid receptor and a distinct non-opioid Tyr-MIF-1-specific binding site with high affinity, attenuating morphine analgesia and tolerance in rodent models. MIF-1 itself also modulates dopaminergic transmission and has been characterised as an antidepressant-like agent in pre-clinical rodent paradigms.
A small-N 1970s/1980s Russian and US clinical literature explored MIF-1 in Parkinson's disease (on the rationale that it would augment levodopa's dopaminergic effect) and depression, with mixed and small-effect results that did not lead to any registration. The Kastin group's decades of work has focused on characterising the Tyr-MIF-1 family's endogenous role in opioid-system modulation and blood-brain-barrier transport, rather than developing MIF-1 as a therapeutic.
MIF-1 has a reported half-life of ~30 min, and the dose intervals researchers model most often fall around once daily. Very short plasma half-life — MIF-1 acts as a single daily pulse rather than building to a steady level. Timing relative to other dopaminergic compounds may matter more than absolute dose. It is catalogued under Memory Peptides on WPA.
7 MIF-1 reconstitution calculations have been logged by the WPA community. The most common dose entered is 10mg (6 calculations). The most common bacteriostatic water volume is 3mL. The most popular vial size is 50mg (7 sessions).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.