Explore MGF (Mechano Growth Factor / IGF-1 Ec) dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
MGF (Mechano Growth Factor), also called IGF-1 Ec, is a splice variant of IGF-1 produced locally in muscle tissue in response to mechanical load and damage, studied for its proposed role in activating muscle satellite cells and initiating local tissue repair. Its unique C-terminal E-domain peptide is the focus of muscle-recovery research. This data shows the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when reconstituting MGF.
MGF (mechano growth factor) is a muscle-specific IGF-1 splice variant studied for muscle-repair research; most products on the market are the synthetic MGF "E-peptide" alone, not the full IGF-1Ec protein. It ships as a lyophilized powder, so confirm which form you're buying and what the certificate of analysis (COA) shows.
The endogenous IGF-1Ec / MGF transcript encodes the same mature IGF-1 peptide as systemic IGF-1Ea but with a distinct C-terminal "E-peptide" extension (the 24-amino-acid "MGF E-peptide" in humans). Most commercial "MGF" peptide products are the synthetic E-peptide alone (residues that follow the IGF-1 portion), not the full IGF-1Ec pre-pro-hormone. The biological target of the E-peptide is debated — some work in C2C12 myoblasts suggests an IGF-1R-independent membrane receptor, but no such receptor has been molecularly identified.
No regulatory approvals anywhere in the world. Research use only, with a small pre-clinical literature in muscle regeneration, cardiac repair, and neuroprotection. **Typical dose:** No human dose has been established. Rodent muscle-regeneration studies have used 25–100 µg/kg by intramuscular injection. Plasma half-life of unmodified synthetic MGF E-peptide is reported in minutes, which is the reason a pegylated variant ("PEG-MGF") is commonly marketed.
MGF IGF-1 Ec has a reported half-life of ~5–7 min, and the dose intervals researchers model most often fall around once daily (post-workout, local). This is the IGF-1Ec splice variant (mechano growth factor); it clears within minutes, so it is used for a brief local pulse with no systemic accumulation. It is catalogued under Muscle Peptides on WPA.
1 MGF IGF-1 Ec reconstitution calculations have been logged by the WPA community. The most common dose entered is 200mcg (1 calculations). The most common bacteriostatic water volume is 1.5mL. The most popular vial size is 2mg (1 sessions).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.