See Kisspeptin-10 dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
Kisspeptin-10 is a neuropeptide that acts as a potent trigger of GnRH pulsatile release, positioning it as a key regulator of the reproductive hormone axis. This data reveals the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when reconstituting Kisspeptin-10.
Kisspeptin-10 is the C-terminal decapeptide fragment of the parent kisspeptin-54 protein encoded by the KISS1 gene, and it is the active sequence that binds the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons. The molecule's significance to the reproductive axis was established by the converging 2003 work of Seminara et al. (Massachusetts General Hospital) and de Roux et al. (Paris), both of whom showed that loss-of-function mutations in GPR54 produce hypogonadotropic hypogonadism and failure of pubertal development — establishing kisspeptin/GPR54 signaling as the master upstream gatekeeper of GnRH pulsatility.
Kisspeptin-10 is the 10-amino-acid active core of kisspeptin, most often sourced for reproductive-axis and libido research because it acts one step upstream of the body's own LH and FSH release. It ships as a lyophilized powder you reconstitute with bacteriostatic water. Note that most published human trials used the longer kisspeptin-54, not the -10 decapeptide.
Kisspeptin neurons in the arcuate and anteroventral periventricular nuclei of the hypothalamus express KISS1R on GnRH neuron terminals; activation triggers pulsatile GnRH release, which in turn drives pituitary LH and FSH secretion and downstream gonadal steroidogenesis. Unlike exogenous GnRH analogs, kisspeptin acts one step upstream and so preserves the body's endogenous pulse architecture.
Investigator-initiated Phase 1/2 trials at Imperial College London and elsewhere have evaluated kisspeptin-10 and the longer kisspeptin-54 isoform as triggers for oocyte maturation in IVF cycles (Abbara et al., reporting reduced ovarian hyperstimulation risk), as diagnostic probes for HH, and in studies of sexual-brain-circuit activation. No marketed product exists; kisspeptin-10 is a research and translational-medicine reagent.
Kisspeptin-10 has a reported half-life of ~4 min, and the dose intervals researchers model most often fall around single dose / once daily. Half-life of only minutes — kisspeptin-10 clears almost immediately and works as a single sharp trigger of LH release rather than building to any steady level. It is catalogued under Testosterone Peptides on WPA.
319 Kisspeptin-10 reconstitution calculations have been logged by the WPA community. The most common dose entered is 100mcg (91 calculations). The median dose across all sessions is 200mcg. The most common bacteriostatic water volume is 3mL. The most popular vial size is 10mg (260 sessions). The most common dosing frequency is daily (7x/week) (29 logged protocols), followed by 3x/week (17).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.