Explore IGF-1 DES dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
IGF-1 DES (DES(1-3)IGF-1) is a truncated, naturally occurring variant of insulin-like growth factor 1 missing the first three N-terminal amino acids, which makes it bind far less to IGF-binding proteins and act more potently but more locally and briefly than full-length IGF-1 or IGF-1 LR3. It is studied for localized muscle and tissue growth effects. This data shows the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when reconstituting IGF-1 DES.
IGF-1 DES is a shortened, more-potent version of IGF-1, sourced in research for muscle and tissue-growth studies because it slips past the binding proteins that limit normal IGF-1. It ships as a lyophilized powder reconstituted before use.
Binds and activates the IGF-1 receptor (IGF-1R) — a tyrosine-kinase receptor — and downstream PI3K/Akt/mTOR and Ras/MAPK signalling. The truncated N-terminus reduces IGFBP-3/5 affinity ≈10-fold, increasing the free-fraction of bioactive ligand in tissues with high binding-protein concentration.
No regulatory approvals. Used as a research tool in the IGF-system literature; no FDA-approved indication and no large clinical trial programme. **Typical dose:** No human dose has been established. Rodent and cell-culture studies have used 1–100 µg/kg subcutaneously or 1–100 ng/mL in vitro.
IGF-1 DES has a reported half-life of ~20–30 min, and the dose intervals researchers model most often fall around once daily (around training). DES(1-3)IGF-1 binds IGF binding proteins poorly, so it clears within minutes and never accumulates — it is used for a brief, potent local pulse rather than systemic buildup. It is catalogued under Muscle Peptides on WPA.
4 IGF-1 DES reconstitution calculations have been logged by the WPA community. The most common dose entered is 20mcg (2 calculations). The median dose across all sessions is 30mcg. The most common bacteriostatic water volume is 2mL. The most popular vial size is 1mg (4 sessions).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.