Discover Epithalon dosage trends, reconstitution volumes, and vial size preferences from anonymized WPA peptide calculator sessions.
Epithalon (Epitalon) is a synthetic tetrapeptide derived from the natural pineal peptide epithalamin, studied for its potential to activate telomerase and support longevity. This data reveals the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when setting up their Epithalon reconstitution protocol.
Epithalon (also spelled Epitalon; chemical sequence Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from the natural pineal-gland peptide complex epithalamin, and it is one of the most distinctive compounds in the WPA dataset because its entire research foundation rests on a single research program with almost no Western replication. The molecule was developed and characterized at the St. Petersburg Institute of Bioregulation and Gerontology by Vladimir Khavinson and collaborators starting in the 1980s as part of a broader "short peptides of bioregulation" program that produced dozens of candidate molecules — Epithalon, Vilon, Thymalin, Cortexin, and others — each marketed in Russia for specific organ-system or age-related indications. , Bull. Exp. Biol. Med.
Epithalon is a research peptide most often sourced for longevity and sleep protocols, typically run as short cyclic courses. It ships as a lyophilized powder you reconstitute with bacteriostatic water before use.
Khavinson's laboratory has reported that epithalon up-regulates telomerase activity in cultured human somatic cells, restoring telomere length in late-passage fibroblasts; the proposed mechanism is direct interaction with the promoter region of the hTERT gene rather than receptor binding. These findings have not been independently replicated by laboratories outside the Khavinson group.
Long-term Russian observational cohorts and one 12-year mortality follow-up in elderly subjects have been published from the Khavinson group, reporting reduced mortality and improved circadian-rhythm markers; methodological limits (non-blinded design, single-site, lack of placebo control in some arms) limit external validity. No Western Phase 2/3 randomized trial has been completed.
Epithalon has a reported half-life of ~30 min (estimated), and the dose intervals researchers model most often fall around once daily (course-based). Cleared from the blood within minutes, so there is no buildup. It is typically run in short courses, and its effects are thought to outlast the dosing. It is catalogued under Anti-Aging Peptides on WPA.
553 Epithalon reconstitution calculations have been logged by the WPA community. The most common dose entered is 5mg (166 calculations). The median dose across all sessions is 4mg. The most common bacteriostatic water volume is 2mL. The most popular vial size is 10mg (366 sessions). The most common dosing frequency is daily (7x/week) (76 logged protocols), followed by once weekly (13).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.