Explore DSIP dosage trends, reconstitution volumes, and vial size patterns from anonymized WPA peptide calculator sessions.
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide studied for its role in sleep modulation and stress response regulation. This data reveals the dose amounts, vial sizes, and bacteriostatic water volumes researchers most commonly select when setting up their DSIP reconstitution protocol.
DSIP — Delta Sleep-Inducing Peptide — is a naturally-occurring nonapeptide first isolated from rabbit cerebral venous blood by Schoenenberger and Monnier at the University of Basel in the mid-1970s. The original Schoenenberger work characterized DSIP as the molecule that induced delta-frequency EEG activity when transferred between sleeping and waking animals, and the molecule has carried that descriptor ever since — even though the published clinical record on DSIP as a sleep agent is, in 2026, considerably thinner than the name suggests. The peptide has been studied in small European clinical series for chronic insomnia, opioid and alcohol withdrawal, and stress-related disorders through the late 1970s and 1980s, with most of that work coming out of Swiss and German groups.
DSIP (Delta Sleep-Inducing Peptide) is a research peptide most often sourced for sleep and stress-axis protocols. It ships as a lyophilized powder you reconstitute with bacteriostatic water before use.
DSIP has been reported to increase EEG delta-wave (slow-wave) activity, modulate corticotropin-releasing hormone secretion, and exhibit weak opioid-like analgesic activity, but no single receptor has been molecularly cloned as the DSIP target. Several authors have proposed an indirect action via the GABAergic and serotonergic systems, while others have failed to replicate the original sleep-induction signal.
Small open-label studies in chronic insomnia, withdrawal syndromes, and chronic pain have been reported across European and Soviet/Russian literature, but no large randomized placebo-controlled trial has confirmed a clinically meaningful effect. DSIP remains primarily a research probe for sleep neurobiology rather than a candidate therapeutic.
DSIP has a reported half-life of ~7–15 min (plasma), and the dose intervals researchers model most often fall around once daily (before bed). Disappears from the blood within minutes, so there is no buildup. It acts as a brief signal, which is why timing it before sleep matters more than the dose size. It is catalogued under Performance Peptides on WPA.
2,277 DSIP reconstitution calculations have been logged by the WPA community. The most common dose entered is 100mcg (452 calculations). The median dose across all sessions is 250mcg. The most common bacteriostatic water volume is 3mL. The most popular vial size is 10mg (986 sessions). The most common dosing frequency is daily (7x/week) (156 logged protocols), followed by once weekly (78).
These figures come from anonymized WPA peptide calculator sessions.
All figures shown are aggregated from anonymized calculator inputs and are provided strictly for independent laboratory research and educational purposes. They are community usage statistics — not dosing recommendations, and not medical advice.